Renal Corpuscle Cell Connectome
Renal corpuscle (also called malpighian body) is the blood filtration unit of the nephron of the kidney. It is composed of a knot of capillaries (glomerulus) surrounded by a double-walled capsule (Bowman's capsule) that opens into a tubule.
Note: Above is a graphic of renal corpuscle. Click the image or Here to see an enlarged image. Copyright: KPMP (Kidney Precision Medicine Project).
Renal corpuscle connectome cell composition:
As shown in the above image, renal corpuscle connectome consists of the following cells and associated components:
- Afferent arteriole endothelial cell (CL_1001096)
- Efferent arteriole endothelial cell (CL_1001099)
- Extraglomerular mesangium mesangial cell (CL_0002173), messangial matrix
- Glomerular capillary endothelium glomerular capillary endothelial cell (CL_1001005 )
- Glomerular mesangium glomerular mesangial cell (CL_1000742 ), mesangial matrix
- Juxtaglomerular granular cell, renin-positive juxtaglomerular granule cell (CL_0000648 )
- Macula densa macula densa cell (CL_1000850)
- Parietal epithelial layer parietal epithelial cell (CL_1000452)
- Proximal tubule (S1) proximal tubule epithelial cell
- Vascular smooth muscle cell (CL_0000359 )
- Visceral epithelial layer podocyte (CL_0000653)
- Podocyte foot (process)
- Parietal base membrane
- Glomerular base membrane
- Thick ascending limb
- Urinary space
Locations (from UBERON)
Kidney (UBERON_0002113), more specifically, kidney nephron (UBERON_0001285).
Lineage
The kidney, including the kidney epithelial cells, arises from OSR1+ mesenchymal progenitor cells in the intermediate mesoderm. Ref: Shankland et al., 2014.
Biological Processes (from GO)
Renal corpuscle has the following associated functions:
- renal filtration (GO_0097205)
- glomerular filtration (GO_0003094)
Images
More to add. Stay tuned ...
References
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